| Sacramento Kings | National Basketball Association | Sacramento | 1945 | ARCO Arena I, Sleep Train Arena, Golden 1 Center, Municipal Auditorium, Kemper Arena, Omaha Civic Auditorium, Cincinnati Gardens, Edgerton Park Arena, Blue Cross Arena |
| Saetas de Oro | Copa Perú | — | — | — |
| Saint Louis City SC | Major League Soccer | Saint Louis | 20 agosto 2019 | Energizer Park |
| Salerno Basket 92 | — | — | — | — |
| San Antonio Spurs | National Basketball Association | — | 1967 | Alamodome, Kay Bailey Hutchison Convention Center, HemisFair Arena, Centro convegni di Fort Worth, Frost Bank Center, Moody Coliseum, Lubbock Municipal Coliseum |
| San Diego FC | Major League Soccer | San Diego | 18 maggio 2023 | Snapdragon Stadium |
| San Diego Padres | Major League Baseball | San Diego | 1969 | Petco Park |
| San Francisco 49ers | National Football League | — | 1946 | Levi's Stadium |
| San Francisco de Asís de Lonya Grande | Copa Perú | — | 1946 | — |
| San Francisco Giants | Major League Baseball | San Francisco | 1883 | Oracle Park |
| San Jose Earthquakes | Major League Soccer | San Jose | 1995 | Avaya Stadium, Buck Shaw Stadium |
| San Jose Sharks | — | — | 1991 | Cow Palace, SAP Center at San Jose |
| San Lorenzo de Almagro de Chiclayo | Copa Perú | — | — | Estadio Elías Aguirre |
| San Martín de Porres de Pucallpa | Copa Perú | — | 9 aprile 1964 | Estadio Aliardo Soria Pérez |
| San Raffaele Basket | — | — | 1978 | — |
| San Simón de Moquegua | Campeonato Descentralizado | — | 1983 | Estadio 25 de Noviembre |
| Santa Marinella Basket | — | — | — | — |
| Santiago Barranco | Copa Perú | — | 20 settembre 1929 | — |
| Santos de Nasca | Copa Perú | — | — | Estadio José Picasso Peratta |
| Scaligera Basket Verona | Serie A | Verona | 1951 | PalaOlimpia |
| Seattle Kraken | — | — | 2021 | Climate Pledge Arena |
| Seattle Mariners | Major League Baseball | — | 1977 | Kingdome, T-Mobile Park |
| Seattle Metropolitans | Pacific Coast Hockey League | Seattle | 1915 | — |
| Seattle Seahawks | National Football League | — | 1976 | Kingdome, Husky Stadium, Lumen Field |
| Seattle Sounders FC | Major League Soccer | Seattle | 2009 | Lumen Field |
| Seattle SuperSonics | — | Washington | 1967 | Kingdome, Climate Pledge Arena, Tacoma Dome |
| Sebastiani Basket Club Rieti | — | — | — | — |
| Senati FBC | Copa Perú | — | — | Estadio Mariano Melgar |
| Serrato Pacasmayo | Segunda División | — | 2012 | Estadio Carlos A. Olivares |
| Sisv Viterbo | — | Viterbo | — | — |
| Società Cestistica Mazzini | — | Bologna | — | — |
| Società Sportiva Basket Napoli | — | Napoli | 1946 | PalaBarbuto |
| Società Sportiva Felice Scandone | Serie B Nazionale | Avellino | 1948 | Palasport Giacomo Del Mauro |
| Sport Boys Association | Torneo Descentralizado | — | 1927 | Estadio Miguel Grau |
| Sport Chorrillos | Copa Perú | — | — | Estadio Campeones del 36 |
| Sport Club Alcamo | — | Alcamo | — | — |
| Sport Coopsol | Segunda División | — | 2000 | Estadio Municipal de Chorrillos |
| Sport Dos de Mayo | Copa Perú | — | — | Union Tarma Stadium |
| Sport Huamanga | Copa Perú | — | 2002 | Estadio Ciudad de Cumaná |
| Sport Inca | — | — | 18 maggio 1908 | Estadio Nacional del Perú |
| Sport José Gálvez | — | — | 1902 | Estadio Nacional del Perú |
| Sport Juan Bielovucic | — | — | — | Estadio Nacional del Perú |
| Sport Pilsen Callao | Copa Perú | — | 1924 | — |
| Sport Sáenz Peña | — | — | 1906 | Estadio Telmo Carbajo |
| Sport Vallejo | Copa Perú | — | ottobre 2002 | Estadio Mansiche |
| Sport Victoria | Copa Perú | — | 1916 | Estadio José Picasso Peratta |
| Sport Águila | Segunda División | — | 25 dicembre 1947 | — |
| Sporting Bellavista | — | — | 1912 | Estadio Nacional del Perú |
| Sporting Club Gira | — | Bologna, Ozzano dell'Emilia | 1945 | — |
| Sporting Club Montecatini Terme | — | Montecatini Terme | 1949 | PalaTerme |
| Sporting Kansas City | Major League Soccer | Kansas City | 1995 | Sporting Park, Legends Field, GEHA Field at Arrowhead Stadium |
| Sporting Pizarro | Copa Perú | — | — | Estadio Mariscal Cáceres |
| Sporting Tabaco (1926–1955) | Campeonato Descentralizado | — | 16 novembre 1926 | Stadio nazionale del Perù |
| Sportivo Melgar | — | — | 14 luglio 1925 | Estadio Nacional del Perú |
| Sportivo Tarapacá Ferrocarril | — | — | 15 ottobre 1911 | Stadio nazionale del Perù |
| SS Lazio Basket | — | Roma | 1932 | — |
| St. Louis Blues | — | — | 1967 | Enterprise Center |
| St. Louis Cardinals | Major League Baseball | — | 1882 | Busch Stadium |
| St. Louis Hawks | National Basketball Association | — | — | — |
| Stamura Basket 1920 | — | — | — | — |
| Starlight Valmadrera | — | — | — | — |
| Stella Azzurra Roma | — | Roma | 1938 | — |
| Sutor Basket Montegranaro | — | Montegranaro | 1947 | PalaRossini |